This study explores the impact of organizational culture factors on innovation capability within Vietnamese enterprises. Based on organizational culture theory and dynamic capabilities theory, the research proposes an integrated model comprising five cultural factors: innovation-supportive culture, continuous learning culture, cross-functional collaboration culture, adaptability culture, and empowerment culture. Using a quantitative research approach with cross-sectional design, data were collected from 225 Vietnamese enterprises through online surveys. Multiple regression analysis results demonstrate that all five cultural factors have positive and statistically significant impacts on innovation capability, with innovation-supportive culture showing the strongest influence (β = 0.287), followed by adaptability culture (β = 0.269). The research model explains 65% of the variance in innovation capability. This study makes significant theoretical contributions to organizational culture literature and provides practical guidance for Vietnamese enterprises in developing organizational culture to enhance innovation capability. The findings suggest that organizations should adopt a holistic approach to cultural transformation, prioritizing innovation-supportive environments while simultaneously fostering adaptability, continuous learning, cross-functional collaboration, and employee empowerment to maximize their innovation potential in an increasingly competitive global market.