Pharmaceutical sales and distribution operations are heavily regulated to ensure the integrity, safety, and efficacy of medicines throughout the supply chain. However, firms often encounter significant challenges navigating complex regulatory environments, particularly across jurisdictions with varying standards and enforcement mechanisms. This paper presents a comprehensive risk management framework designed to support pharmaceutical companies in identifying, assessing, and mitigating compliance risks associated with sales and distribution activities. Drawing on existing compliance models, pharmaceutical governance literature, and real-world case data, the study synthesizes best practices into a conceptual model that integrates regulatory intelligence, operational controls, and stakeholder collaboration. The framework is validated through expert feedback and retrospective analysis of compliance breaches in low- and middle-income country contexts. By focusing on proactive risk identification and response alignment, this model aims to enhance organizational resilience and regulatory alignment across global markets.