Abstract

Fever is managed using synthetic drugs such as aspirin, paracetamol and other drugs has more adverse effects. Traditional medicine employing a plant-based system treatment from an important part of human medicine system. It has less side effects, adverse effects when compared with synthetic drugs. The present study is aimed to investigate the comparison of anti- pyretic activity of ethanolic extract of Premna latifolia species.
The present study is aimed to investigate the antipyretic activity of ethanolic leaf extract of Premna latifolia in Wistar albino rats. Pyrexia was induced in rats by Brewer’s yeast suspension. The animals were divided in to 4 groups, 6 of each as following Group I received normal saline water (control); Group II received standard paracetamol 150 mg/kg; Group III, IV received ethanolic leaf extract of Premna latifolia at doses 100, 200 & 300 mg/kg respectively. In all experiments, rats were orally administered. The temperature of all the rats in each group was measured at the start of study, at 18 h after yeast injection and every hourly for 4 h thereafter. The mean temperature was found out for each group and was compared with the control group and standard drug group. The leaf extract at doses 200 and 300 mg/kg significantly reduced the body temperature on yeast induced pyrexia and was comparable with standard.