Degenerative arthropathies of the talus are quite common following ankle sprains in young and active patients. Once the tissue is damaged, it has poor healing capacity, and therefore the injury may even become irreversible and chronic. The treatment has been widely discussed, and there are various surgical proposals aimed at restoring the cartilage on the talus; however, among these, only osteochondral grafting and the administration of autologous chondrocytes have demonstrated the ability to regenerate and repair the injured site. Ankle osteoarthritis is a chronic condition with a progressive course; therefore, conservative treatment only has a delaying effect on degeneration and remains secondary to the definitive option of surgery. Although regenerative techniques have limitations, unlike conservative treatment, they are able to delay the need for surgical intervention. Therefore, with the goal of reaching surgical treatment for degenerative ankle arthropathies as late as possible, the transplantation of autologous bone marrow-derived stem cell infiltrates has been proposed, maximizing the benefits of their self-renewal and replication capabilities.