Abstract

Introduction: Postoperative anastomosis leaks (AL) are still common and serious complications of lower colorectal surgery in that they are a major cause of mortality and morbidity from the procedure. Liquid-based fibrin sealants have also been studied to prevent intestinal leakage after anastomosis. The aim of this review is to learn about the use of autologous fibrin glue (AFG) in bowel anastomosis written in the form of a systematic review.
Methods: This research is qualitative research with a research methods systematic review. Researchers obtained sources taken from electronic search engines via PubMed, Google Scholar and ScienceDirect using the keywords “Fibrin glue or Fibrin Sealant for Bowel Anastomosis or Surgery " based on inclusion and exclusion criteria set by author. This research was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines.
Result: In the meta-analysis examining the effects of fibrin glue on anastomosis complications, including leak, fistula, and bleeding, the findings suggest no significant impact of fibrin glue. The relative risk (RR) for anastomosis leak was 0.92 (95% CI: 0.67 - 1.25, p = 0.58), indicating no substantial difference between the fibrin glue group and controls. Similarly, the RR for fistula was 0.64 (95% CI: 0.35 - 1.17, p = 0.15), and for bleeding, it was 0.68 (95% CI: 0.12 - 3.83, p = 0.66), neither reaching statistical significance.
Conclusion: Although it is difficult to conclude from the currently available evidence provided in this analysis, the use of AFG in bowel anastomosis is promising to improve clinical outcomes, reduce mortality and postoperative complications. Nevertheless, further research in humans with larger sample sizes is necessary to determine the benefits and superiority of AFG, as well as to establish a clinical recommendation of its usage.