As per Ayurveda principles tri-upstambh plays a significant role in physical social and mental wellbeing of a human being. First upstambh i.e. ahara plays a very basic and important role out of three. Its importance has increased more into today’s era due to tremendous change in food and life style. Use of food preservatives, adulteration, food processing, use of artificial food substances and new combinations of food has spoiled our generation and made our body system week and hollow. There is no other way out, so world is looking towards age old science Ayurveda which can help us to save ourselves. Ayurveda talks about aahar vidhi, aahar vishesh aytanam. Ayurveda experts have given detailed description about Viruddha Aahar and described its 18 types with examples in samhitas. There is need to go through it and understands its basic importance and its utility in today’s era to prevent our self from unwanted autoimmune, chronic untreatable diseases. This article entitled Understanding food incompatibility according to Ayurveda principles is just the first step in this direction. Viruddha ahar acts as a slow poison vitiating all sapta dhatus and leading to major health problems and even genetic changes.