Oral drug delivery films (ODFs) have emerged as a patient-centric alternative to conventional oral dosage forms, offering significant advantages in terms of convenience, compliance, and safety. Designed as thin, flexible strips, ODFs disintegrate or dissolve rapidly in the oral cavity, enabling self-administration without the need for water or chewing. This unique feature makes them especially suitable for pediatric and geriatric populations, bedridden patients, and individuals with swallowing difficulties (dysphagia), Parkinson’s disease, mucositis, nausea, or vomiting. By minimizing the risk of choking and enhancing therapeutic compliance, ODFs have gained wide acceptance as fast-dissolving drug delivery systems. Their adaptability in terms of size, shape, and formulation further supports their role as a promising platform in modern drug delivery. This review explores the potential of ODFs as a patient-centric approach, highlighting their formulation aspects, therapeutic applications, and future scope in addressing unmet clinical needs.