Sari rapet herbal medicine is one of the medicines frequently consumed by the Madurese people, especially Sumenep Regency, for generations. The use of sari rapet herbal medicine aims to tighten female muscles and reduce vaginal discharge, however, the use of sari rapet herbal medicine has not yet gone through pre-clinical trials. This study aims to determine the effect of sari rapet essence herbal medicine on the histology of the kidney and liver organs of rats (Rattus novergicus). This type of research is True Experiment Research with a post-test-only control design method. The samples used were mice divided into four groups with different treatments, namely 0 g/200gBW, 0,54 g/200gBW, 1,08 g/200gBW, and 1,62 g/200gBW for 28 days a day. Histological changes data will be analyzed using the Shapiro-Wilk test and One-Way Annova. The research results showed that there was damage in all groups with the highest level of damage in group 3 (1.62 g/200gBW). The conclusion shows significant differences in kidney degeneration organ damage and inflammatory cell infiltration. Significant differences exist in bridging necrosis damage, degeneration focal necrosis, and inflammatory cell infiltration in the liver.