Abstract

Severe Acute Respiratory Syndrome (SARS-CoV-2) is a new type of coronavirus that has never been identified in history. SARS-CoV-2 is the virus that caused the COVID-19 pandemic. The disease caused by SARS-CoV-2 can be prevented through vaccines and antivirals, but the effort in providing and purchasing products from vaccines is quite expensive and time consuming. Herbal plants have long been used by local communities as a way to prevent a disease, one of which is caused by a virus. The purpose of this study is to determine the bioactive compounds of compounds in three herbal plants (Curcuma xanthorrhiza, Zingiber officinale, and Cinnamomum burmanii) that can be used as an ammunizer in preventing SARS-CoV-2 in silico. The research method is in silico, with computational techniques using computer applications by testing through analysis of physicochemical properties, pharmacokinetics, toxicity, and molecular docking. The results obtained from physicochemical properties, pharmacokinetic properties and toxicity that six compounds have met the requirements of safe as oral drugs and potential as new drug candidates. The results of docking between six ligand compounds and ACE2 protein have a good interaction bond in inhibiting receptor activity and produce interaction visualization results in the form of amino acid residues. A study on predicting the activity of bioactive compounds conducted on six herbal compounds showed that the compounds had moderate or good activity as bioactives capable of fighting viruses.