Abstract

The objective of the present study was to formulate and characterize an optimal stable Nano emulsion formulation of Saquinavir with an aim to increase its bioavailability. The components for the formulation of Nano emulsion were olive and Clove oil selected as the oil phase, surfactants namely Tween 40 and the co-surfactants, Ethanol were selected. Different concentrations of oil and surfactant, which formed nanoemulsions were selected basedon the thermodynamic stability and dispersibility test. Optimized formulation was selected for in vitro study on thebasis of higher drug release, optimum globule size, minimum lower viscosity, and overalllower surfactant concentration and co-surfactant. The diffusion of drug from Nano emulsion for the all the prepared formulations. Thusoptimized nanoemulsion could be used effectively to improve the bioavailability of poorly water-soluble drugs toimprove their bioavailability. The nanoemulsion were optimized optical transparency, viscosity measurement, determination of pH, measurement of globule size, zeta potential, drug content, invitro diffusion study, stability study.