The current study aimed to study the effect of synthesized silver nanoparticles using Melia azedarach L.leaf extract by dipping and feeding methods at four concentrations (200, 100, 50,25) ppm in the stages of the house fly Musca domestica L.,the concentration of200 ppm caused an emergence inhibition rate of 100 %, while the lowest inhibition rate was at a concentration of 25ppm, which amounted to 53% by dipping method after ten days of treatment, while the value of LC50 (the concentration that kills 50% of insects) reached (24.23) ppm. While the percentage of inhibition by feeding method also reached 100% at a concentration of 200 ppm, and the concentration of 25 ppm gave the lowest inhibition rate of 48% and for the same time period, and the value of LC50 (27.06) ppm. For both methods, the results also showed that all concentrations had an effect on the natural development of the growth of the different stages and caused the appearance of morphogenetic abnormalities in the pupa and the adult and a decrease in the percentage of the appearance of the adult. The results showed that the effect of silver nanoparticles by dipping method was higher than by feeding method for all phases.