The high-risk nature of project-based organizations (PBOs) demands systematic approaches to safety that go beyond episodic interventions. Despite extensive safety programs, incidents and near-misses continue to occur due to fragmented implementation, inconsistent adherence, and weak organizational learning mechanisms. This study proposes a conceptual model for institutionalizing life-preserving safety practices across project-based organizations, aiming to embed proactive safety behaviors, processes, and governance into organizational structures. The model integrates human, technical, and organizational factors, emphasizing the interplay between individual competencies, team coordination, leadership engagement, and digital safety tools. Core components include safety leadership and governance, standardized procedures, hazard identification and risk assessment mechanisms, competency assurance, and communication systems. The model further identifies moderating variables such as safety culture and climate, and mediating mechanisms including real-time monitoring, incident reporting, and lessons learned repositories. Through a process-oriented framework, the model outlines pathways for codifying best practices into organizational routines, reinforcing continuous learning, and establishing feedback loops that prevent recurrence of unsafe behaviors. The framework also emphasizes the strategic role of digital tools, predictive analytics, and real-time dashboards in enabling proactive interventions and enhancing situational awareness. By bridging individual, team, and organizational dimensions of safety, the model offers a systems-based approach to reduce accidents, improve project performance, and institutionalize a culture of life-preserving behaviors. Its adoption can enhance compliance, resilience, and operational efficiency across complex projects, providing a replicable template for high-hazard industries. This conceptual study contributes to the safety management and project governance literature by providing an integrative model that links organizational learning, leadership, and technology with sustained safety performance. Future research should empirically validate the framework across multiple industries and project types, evaluating its effectiveness in reducing incidents and embedding enduring safety practices.