The increasing recognition of Autism Spectrum Disorder (ASD) highlights the caregiving burden experienced by parents. This study aimed to determine the challenges, coping mechanisms, and stress of parents of children with ASD in CALABARZON and examined the relationships among these variables. The study used a descriptive–correlational design with 163 respondents. Data were gathered using a validated questionnaire and analyzed through weighted mean and Pearson r. Results show very high caregiving challenges, high coping mechanisms, and high stress levels among parents. Findings also reveal a very weak but significant relationship between challenges and coping mechanisms, while no significant relationships were found with stress. The conclusion is that despite coping strategies, parents continue to experience high stress, highlighting the need for strengthened support systems and the proposed P.A.R.E.N.T.S. Resilience Framework.