Throughout history, humanity has suffered from the scourge of potentially fatal viral and parasitic diseases. The objective of the research was to analyze the population dynamics of the Aedes aegypti mosquito species over the last six years in the province of Villa Clara, Cuba. The research was carried out in Villa Clara province, and covered the 13 municipalities. An observational, descriptive, ecological, retrospective, and statistical study was conducted using data stored in an Excel database. The study covered the period from 2020 to 2025, encompassing all 13 municipalities. The total number of Ae. aegypti mosquito breeding sites (larval stage) reported by these municipalities during the six years analyzed was entered into this database. The primary data come from official records aggregated monthly, organized into two main dimensions: Temporal dimension: monthly time series (January–December) for each year of the study period. Spatial dimension: disaggregated by the province's 13 municipalities. The integrity of the database was verified, and no imputation of missing data was required for the selected subset. Regarding the municipalities with the highest incidence, Santa Clara stands out as the most prevalent, followed by Placetas, Sagua la Grande, Manicaragua, and Caibarién. As for the monthly incidence, June stands out, followed by November, July, October, September, and August. The overall annual trend for Ae. aegypti infestations in Villa Clara province during the six years covered by the study was downward. It is concluded that arboviral infectious diseases are closely related to climatic seasonality, which confirms the seasonal cyclical behavior of mosquitoes.