This study represents the initial stage of e-module development using the ADDIE model, namely the needs analysis stage. The purpose of this study was to identify students' and lecturers' needs for the development of a STEM-based General Chemistry e-module integrated with PhET Simulations on chemical bonding. The needs analysis was conducted through curriculum analysis, analysis of student characteristics, analysis of learning media, a student needs questionnaire, and interviews with the course lecturer. The study was conducted in the Chemistry Education and Biology Education Study Programs at Universitas Muhammadiyah Tapanuli Selatan, involving 18 students as questionnaire respondents. The questionnaire instrument consisted of 20 statement items mapped into four C4 dimensions: critical thinking, collaboration, creativity, and communication. The analysis showed that the overall mean student response was 4.02 on a 5-point scale, or 80.39%, with a positive response rate of 83.61%. The collaboration dimension obtained the highest score (M = 4.14; 82.89%), followed by critical thinking (M = 4.01; 80.22%), creativity (M = 3.97; 79.33%), and communication (M = 3.96; 79.11%). These findings indicate that students have good initial readiness, but they still need more interactive teaching materials to strengthen their ability to solve HOTS problems, generate new ideas, develop alternative solutions, and explain chemistry concepts orally. Lecturer interview results also indicated the need for innovative teaching materials capable of visualizing abstract concepts in chemical bonding, integrating STEM activities, and facilitating students' C4 skills. Thus, the development of a STEM-based General Chemistry e-module integrated with PhET Simulations is considered relevant and necessary as a follow-up to the design and development stages of the ADDIE model.