The aim of this study was to investigate the effectiveness of a strategy based on the development of solid lipid Nanoparticles as an innovative formulation of Artemisia arborescens with improved therapeutic efficacy. Artemisia arborescens SLNs were prepared by Solvent evaporation method using Phosphotidyl choline as lipid and Tween 80 as surfactant. The SLN formulation particle size was determined. The change of particle charge was studied by zeta potential (ZP) measurements. In vitro release studies of the essential oil were performed at 35°C. Data showed a high physical stability for both formulations at various storage temperatures during 2 months of investigation. The solubility of drug in different solid lipids was measured. FTIR studies indicated no interaction between drug and lipid. SLN were characterized for particle size, zeta potential, entrapment efficiency and surface morphology. In vitro drug release studies were performed in phosphate buffer of pH 7.4 using dialysis bag diffusion technique. The F6 formulation had shown maximum entrapment up to 90.12 
% and sustained drug release for 8 h. The scanning electron microscopy and zeta potential study showed formation of good SLN dispersion. The stability study showed successful formation of stable SLNs.