This study focused mainly on determining the concentration that will produce the highest male percentage using the Pepper Leaf Powder (PLP). It also evaluated the effect of PLP on the growth and survival of the treated fish and the cost analysis on the use of the indigenous hormone. The study was done into two phases: Range Finding Test and Definitive Test Run (DTR). For DTR, the PLP inclusion levels were tested at 0.5% interval per treatment. The treatments were: T₁ with 5.5% PLP, T₂ with 6.0% PLP and T₃ with 6.5% PLP inclusion. Newly hatched fry were stocked in 50-L aquarium and fed ad libitum with the PLP-treated feeds for 28 days. Then the fish were nursed in tank for 35 days after which the sex of each fish was determined by examination of the genital papilla. The samples that sex was not easily identified were subjected to gonadal examination. Mean percentage male ranged from 72% (T1) to 80% (T3). However, statistical analysis for the percentage male for the DTR showed no significant differences among the treatment means. Increasing the inclusion of PLP in the feed also increases the percentage of male which indicates that higher concentration of PLP should be tried in future studies to increase the percentage sex reversal. Treatment 3 showed the highest value in terms of weight gain (15.64g ± 0.46), length gain (91.55 mm ± 1.82). and survival rate (84.8%). In the cost and return analysis, net profit of PhP 2,706.8 with Php 1.1 per fish and ROI of 38.92% were attained using PLP in the sex redirection of tilapia.