The need to revive the entrepreneurial mindset of the youths for self and economic development necessitated the study. This becomes pertinent as the level of poverty and rate of unemployment of the youths keep increasing in Nigeria, it therefore behooves on the stakeholders (parents, guardians, teachers, religious groups and government) to look inward and revive the entrepreneurial spirit of the young people so as to minimize job seekers and increase job creators in order to reduce the unemployment of the youths. This paper therefore discusses the strategies that could be used to revive, rejuvenate and reposition the entrepreneurial culture to minimize unemployment and enhance youths’ economic development for self-reliance.