This study aims to present opportunities and challenges for Vietnamese enterprises about the change in consumer behavior in the post-Covid-19 era. Is a new topic and not a single mentioned or available article yet. The research has selected a number of articles related to consumer behavior that can collect analytical data, predict the situation and give specific factors for the research. The research results show that in the post-Covid-19 period, businesses can still seize many opportunities for them to return to normal. In particular, the factor of changing consumer behavior is most necessary for businesses, a new sales mindset will be really necessary for businesses today when the epidemic in the world is still. going complicated. This is also the period when businesses can re-screen their personnel and make better policies, with better plans for the upcoming plans, businesses can also confirm their products in the market. Which businesses really stay strong in the consumer industry and seize opportunities to bring their businesses out of this crisis. In addition to the opportunities, after the post-Covid-19 period, Vietnamese businesses face many challenges when the Covid translation is not completely finished, the worrying thing about the business is its finance, personnel, especially the consumer behavior of customers after Covid-19 has changed, they choose safer products, fear of risks than before. From the perspectives on opportunities and challenges, the research has also given a number of solutions that can help businesses refer and give directions for businesses in this period.