The current study was conducted in two localities have been selected in Western Kordofan State (Elsonout and Abu-zabad) to evaluate the similarities and differences in Heavy Metals Concentrations (Copper, Cadmium, Zinc, and Lead) in three parts (Liver, Gills and Muscles) of Catfish cultured in Dams. Moreover, the study was intended to evaluate the similarities and differences in Heavy Metals Concentrations in Dams water where Fish are cultured. The Correlation of Heavy Metals Accumulation between fish organs and water samples were compared. Finally, the evaluation was done for the comparison of these Heavy Metals levels with recommended levels by FAO, WHO and other international organizations. A total of 54 samples has been taken from marketable size Catfish (Gills; Livers and Muscles) cultured in Dams (Elsonout and Abu-zabad localities) were subjected to analysis Heavy Metals accumulations (Copper, Cadmium, Zinc, and Lead. Moreover, A total of 18 water samples were taken from Dams (shallow, middle and deep water) where fish samples has been taken. The data was subjected to SPSS by using factorial design. These findings were revealed that, There were a highly significant differences (p≤0.01) in all Heavy Metals among Gills, Liver and Muscles of Clarias brachysoma cultured in Dams (Elsonout and Abu-zabad localities). Anyway, Gills were recorded the maximum figures in all Heavy Metals followed by Livers and the minimum figures were recorded by muscles. These results were in the permissible levels recommended by international organizations. According to the findings.