This study is intended to present opportunities and challenges for Vietnamese real estate brokerage firms in the post-Covid-19 era. The research has selected a number of articles related to real estate to collect data to analyze, predict the situation and give specific factors for the research. Research results show that in the post-Covid period, real estate brokerage firms were still able to seize many opportunities for them to return to normal. In particular, the element of changing thinking in business is really the most necessary factor for businesses, a new sales mindset will be really necessary for businesses today when the world epidemic. still going complicated. This is also the period when real estate brokers can refine their staff and make better policies and plans for the upcoming plans, businesses can also confirm their products. market. Any business that truly stands firm in the real estate brokerage industry and seizes the opportunities to bring its business out of this crisis. In addition to the opportunities, after the post-Covid-19 period, Vietnamese businesses face many challenges when the Covid-19 pandemic is not over yet, the worrying thing about the business is its finance, personnel, especially, the behavior of customers buying land after Covid-19, they choose safer and more risk-averse products. From perspectives on opportunities and challenges, this research also gave a number of solutions that could help brokerage businesses to refer to and give themselves business directions in this period.