Knee osteoarthritis is a common cause of knee pain in middle aged and elderly patients presenting in Orthopaedic Out- patient clinics in Nigeria. This study compared the pain control using the visual analog scores (VAS), improvement in function using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) scores. Patients over 40 years with radiographically and clinically confirmed osteoarthritis of the knee (Kellegren and Lawrence Grade 1 and 2) who met study criteria were recruited with informed consent taken. The patients were randomized into 2 groups. Group A had a single intra-articular injection of 20mg triamcinolone acetonide (Kenalog) and Group B had oral Meloxicam (Melocap) 7.5 mg for 12 weeks. They had functional and pain scoring at intervals of 0, 1, 6, and 12 weeks using a (WOMAC) and the VAS respectively. Both study groups showed statistical difference in pain control (VAS) over the study period in the 6^th and 12^th week. There was however a statistically significant change in functional scores (WOMAC) in both study groups at Week 1, 6, and 12 (p<0.05).