Objective: This article compares the effects of two different methods on dissolving piperacillin sodium and tazobactam sodium for infection to improve nursing efficiency.

Methods: According to the random number table method, 80 bottles of piperacillin sodium and tazobactam sodium of the same manufacturer, batch number, and specification were divided into control group and experimental group, with 40 bottles in each group. The control group shook the medicine evenly by the method of holding the "bottleneck and bottle"; The experimental group shook the medicine evenly by the method of holding the "bottleneck and bottle" combing with knocking between corks, after shaking the vial twice up and down. The dissolution time and dissolution adequacy of the two groups of powder drugs are observed and compared.

Results: The experimental group was better than the control group in terms of drug dissolution time and dissolution adequacy, and the difference between the two groups was statistically significant (P<0.05).

Conclusion: After shaking the vial twice up and down, the method of holding the "bottleneck and bottle" combing with knocking between corks can not only shorten the dissolution time of the powder and improve the efficiency of nurses, but also make the medicine fully dissolved and ensure the accurate dosage of the medicine.