The use of Personal Protective Equipment (PPE) is one of the risk control efforts that aims to protect health workers from occupational safety and health hazards. Personal Protective Equipment (PPE) is a must that must be used by doctors and nurses in serving patients during the COVID-19 pandemic. Personal protective equipment (PPE) is an alternative preventive measure for health workers in protecting themselves from the risk of transmission. However, the responsibility for using PPE is on every health worker. Factors that can determine compliance in the use of PPE by doctors and nurses are knowledge, supervision, action, attitude, and motivation. This study aims to determine the factors related to compliance with the use of personal protective equipment (PPE) by doctors and nurses during the covid19 pandemic at the Mandau District Hospital, Bengkalis Regency in 2021. This type of research is a quantitative study with a Cross Sectional Study design. The location and time of the study was at the Mandau District Hospital from March to June 2021. The sample of this study were 30 doctors and 35 nurses at the Mandau District Hospital. The sampling technique used is the Total Sampling Technique. The results of the research are knowledge p value = 0.000, supervision p value = 0.002, action p value = 0.004, attitude p value = 0.339 , motivation p value = 0.001 . It can be concluded that there is a relationship between knowledge, supervision, action, motivation and there is no relationship between attitudes and the use of PPE.