Buruli Ulcer is a chronic, necrotizing indolent disease. It is a neglected tropical disease caused by the environmental bacterium called Mycobacterium ulcerans which may affect the skin, tissues and bones. Its mode of transmission remain a challenge to public health. A hospital based study to determine the prevalence of Buruli ulcer in parts of Jigawa State Nigeria was conducted between December 2019 and September, 2021. The purposive sampling techniques was adopted and findings were subjected to patients across all age groups in both male and female gender. The result of this study has revealed negative results for the three hundred and eighty two (382) suspected patients for Buruli ulcer disease, using the Ziehel Nelseen staining technique. Questionnaires were administered to four hundred and eighty (480) respondents in the community, and responses from the questionnaire were used to determine Knowledge, Attitude, practices, perception and risk factors for Buruli ulcer in all the local governments of Jigawa State, where this research was conducted. Results from test analysis and responses generated from the questionnaire were reduced to percentages and presented on tables. Chi-square shows that there exist significant relationship between the socio-demographic characteristics of respondents and Knowledge, Attitude, perception, practices and risk factors for Buruli ulcer at 5 % probability (P≤0.05). Further finding should be done with emphasis on sampling of clinical specimens from a community based study.