The study investigated the occupational hazards of sanitation workers in Port Harcourt metropolis, Rivers State, Nigeria. The study was guided by 4 objectives, 4 research questions. The study had an estimated population of 960 sanitation workers in Port Harcourt metropolis, a multistage sampling method was employed, and a sample size of 621 was derived using Taro-Yamen formula. The study collected data from the following groups of sanitation workers; domestic cleaners (314), industrial cleaners (248), refuse collectors (13), street sweepers (9) and fumigators (9) who are all involved in keeping our environment tidy.The study adopted a descriptive cross sectional research design, instrument used for data collection was a close ended structured questionnaire with a reliability of 0.87 obtained using Cronbach alpha. Data were analyzed using mean and standard deviations to analyze demographics, a z-test and one way ANOVA were used to test the hypothesis at 0.05 level of significance. The study revealed that sanitation workers had high exposure to chemical hazards (2.76±1.094) compared to a criterion mean of 2.50, moderate exposure to physical and biological hazards (2.53±1.032 & 2.58±1.040 respectively), and low exposure to psychosocial hazards (2.33±1.029). The study concluded that sanitation workers in Port Harcourt were exposed to occupational hazards by varying degrees and were experiencing health effects associated with the hazards. Based on the findings of the study, there is need for education of sanitation workers on safety practices. The study recommended that administrative measures be taken to improve safety statistics, periodic safety trainings be organized, and the consistent use of Personal protective equipments should be encouraged.