This study investigated the prevalence of occupational hazards on truck drivers in Rivers State. The cross-sectional descriptive survey research design and the is Rivers State. The population for this study comprised of all 3000 registered industrial truck drivers in Rivers State. The sample of this study was 500 truck drivers. The study adopted simple random sampling technique. Data collection for the study was collected through the use of structured questionnaires. The questionnaire was titled: ‘Prevalence of Occupational Hazards among Truck Drivers Questionnaire (POHTDQ). A structured questionnaire was used for data collection and analysis was done using descriptive statistics such as percentage, mean and t-test. The finding of the study showed that there is no significant difference between the mean responses of drivers and the prevalence of fatigue among truck drivers in Rivers State [tcal (1.22); t-crit (1.96); p>0.05]; there is no significant difference between the mean responses of drivers and the prevalence of biological hazard among truck drivers in Rivers State [tcal (1.23); t-crit (1.96); p>0.05]; amongst others. The study concluded that amongst the prevalence of occupational hazards includes: fatigue and biological hazard, among truck drivers in Rivers. It was recommended that, industries and Managers should improve work policies and procedures, and provide personal government should encourage Truck drivers through counseling or seminars to take regular sleep schedule, healthy diet and frequent exercise to help reduce fatigue. They should also be encouraged to consume less caffeine during the day and avoid caffeine at night which may also help.