The third mission appears as a bridge between Higher Education Institutions and their environment, becoming a key element for solving current problems that hopelessly need a dynamic response in real time. Through the transfer of knowledge and technology, Higher Education Institutions stimulate industry and society, becoming a key agent in the approach to innovation and entrepreneurship, as a facilitator for sustainability development. This study aims to understand the benefits of Higher Education Institutions Third Mission dynamics as a stimulating factor in the globalisation of the economy and the evolution of the community, the global development of industry and the evolution of society. It uses a case study of the 1st Batch of the DEMOLA Project, developed in the 1st semester of 2021, at the Polytechnic Institute of Cávado and Ave, Portugal. Results seem to show that co-creation projects develop a big set of the needed 21^st skills among all participants as well as enhance the interaction between HEI and its stakeholders, based on competitiveness and sustainable development.