The Agnimantha i.e Premna serratifolia Linn. Synonym Premna integrifolia Linn is a large, thorny deciduous shrub or a tree, up to 9 meters in height, commonly seen at Indian and the Andamans coasts. The Agni means fire and Mantha means churning. When the plant woods rubbed each other, generate fire, so named as Agnimantha. In Ayurveda the roots and leaves are most used parts for various medicinal preparations. The roots are considered as astringent, stimulant, liver tonic, laxative, carminative and antibacterial. Leaves infusion with pepper is useful in cold and fever, leaf sap is useful to alleviate headache. It can be used as hypoglycemic, anthelmintic, aphrodisiac, anti-inflammatory, analgesic and antimicrobial agent. It cure diseases like urticaria, asthma, haemorrhoids, erysipelas, fever, worms, allergic conditions. It is described in one of the ingredient in Dashamoola. The Agnimatha is of two types Viz; Laghu Agnimatha(Premna integrifolia Linn), and Brihat Agnimantha(Clerodendrum phlomidis Linn). The present review dealt with the brief introduction and pharmacological actions, its traditional uses, modern research activities and also discussed the botanical description, chemical composition, biological activities on the basis of digital scientific database