This study investigates how interlocking stabilized soil blocks (ISSB) can serve as a viable and environmentally friendly alternative to traditional building materials in residential architecture. The study aims to evaluate the production, installation, and post-occupancy performance of ISSBs. This is accomplished by conducting a critical analysis of the experimental project that was carried out at Obayemi House, which is a semi-detached bungalow with two bedrooms located in Redemption Camp, Nigeria. In this investigation, a mixed-methods approach is utilized, which combines empirical data, and post-occupancy surveys with theoretical frameworks derived from sustainable design and performance-based architecture. This research focuses on key parameters such as the selection of raw materials, mix ratios, construction techniques, thermal insulation, durability, and economic feasibility. A comparison with traditional materials, such as fired bricks and concrete blocks, demonstrates that ISSBs have the potential to lessen their impact on the environment, reduce the costs of construction, and improve the comfort of occupants. According to the findings, ISSBs continue to face challenges in terms of aesthetics and moisture control in wet areas, despite the fact that they offer significant advantages in terms of sustainability, ease of construction, and rapid assembly. This study not only contributes empirical evidence towards sustainable material research but also provides recommendations for optimizing ISSB production and integration into broader architectural practices.