This study examined the experiences of missionary sisters caring for vulnerable individuals in San Pablo City, Laguna, focusing on their coping mechanisms and the challenges they face, particularly their physiological and psychological struggles. Using a phenomenological approach, the research identified key themes of caregiving, spirituality, and community support. The findings emphasized the sisters’ commitment to holistic care, the role of faith in overcoming difficulties, and the need for self-care and emotional balance. The study recommended strategies to enhance their well-being and called for increased support from local governments and NGOs to sustain their vital work.